Theophylline

Excreted Unchanged %
<10
Half-Life (Normalesrd) Hours
4-12/Unchanged
Plasma Protein Binding %
55
Volume Of Distribution L/Kg
0.4-0.7
Dose For Normal Renal Function
6.0 mg/kg load, then 9 mg/kg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 125% during dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Borgstr&#246; m L, Liu CX, Walhagen A. Pharmacokinetics of the enantiomers of terbutaline after repeated oral dosing with racemic terbutaline. Chirality. 1989; 1: 174-7. [PMID: 2642046] / Borgstr&#246; m L, Nyberg L, J&#246; nsson S, Lindberg C, Paulson J. Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemate. Br J Clin Pharmacol. 1989; 27: 49-56. [PMID: 2706188]
Toxicity Notes
May exacerbate uremic gastrointestinal symptoms. Pharmacokinetics vary widely among similar patients and cannot be predicted by age, sex, weight, or other demographic characteristics.