Half-Life (Normalesrd) Hours
5.5
Plasma Protein Binding %
96
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
1-2 inhalations bid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Cazzola M, Testi R, Matera MG. Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet. 2002; 41: 19-30. [PMID: 11825095]
Toxicity Notes
Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation.