Excreted Unchanged %
No data
Half-Life (Normalesrd) Hours
1.6/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
4.6
Dose For Normal Renal Function
2 inhalations qid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Ensing K, de Zeeuw RA, Nossent GD, Koë ter GH, Cornelissen PJ. Pharmacokinetics of ipratropium bromide after single dose inhalation and oral and intravenous administration. Eur J Clin Pharmacol. 1989; 36: 189-94. [PMID: 2524387]
Toxicity Notes
Ipratropium is not readily absorbed into systemic circulation either from the surface of the lung or from the gastrointestinal tract as confirmed by blood level and renal excretion studies.