Half-Life (Normalesrd) Hours
1.8-2.3/12
Plasma Protein Binding %
<3
Volume Of Distribution L/Kg
0.8
Dose For Normal Renal Function
Up to 15 mg/kg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
75% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Lee CC, Wang LH, Majeske BL, Marbury TC. Pharmacokinetics of dyphylline elimination by uremic patients. J Pharmacol Exp Ther. 1981; 217: 340-4. [PMID: 7229976]