Half-Life (Normalesrd) Hours
2-4/4
Plasma Protein Binding %
7
Volume Of Distribution L/Kg
7.2-9
Dose For Normal Renal Function
2 inhalations q4-6h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Anderson PJ, Zhou X, Breen P, Gann L, Logsdon TW, Compadre CM, et al. Pharmacokinetics of (R,S)-Albuterol after aerosol inhalation in healthy adult volunteers. J Pharm Sci. 1998; 87: 841-4. [PMID: 9649352] / Boulton DW, Fawcett JP. Pharmacokinetics and pharmacodynamics of single oral doses of albuterol and its enantiomers in humans. Clin Pharmacol Ther. 1997; 62: 138-44. [PMID: 9284849] / Mohamed MH, Lima JJ, Eberle LV, Self TH, Johnson JA. Effects of gender and race on albuterol pharmacokinetics. Pharmacotherapy. 1999; 19: 157-61. [PMID: 10030766] / Morgan DJ, Paull JD, Richmond BH, Wilson-Evered E, Ziccone SP. Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate. Br J Clin Pharmacol. 1986; 22: 587-93. [PMID: 3790406] / Powell ML, Chung M, Weisberger M, Gural R, Radwanski E, Symchowicz S, et al. Multiple-dose albuterol kinetics. J Clin Pharmacol. 1986; 26: 643-6. [PMID: 3793958] / Rey E, Luquel L, Richard MO, Mory B, Offenstadt G, Olive G. Pharmacokinetics of intravenous salbutamol in renal insufficiency and its biological effects. Eur J Clin Pharmacol. 1989; 37: 387-9. [PMID: 2598971]
Toxicity Notes
Because of its gradual absorption from the bronchi, systemic levels of albuterol are low after inhalation at recommended doses. Nebulized albuterol therapy decreases plasma potassium concentrations in patients on hemodialysis.