General Toxicity Notes
May decrease renal function. Decrease platelet aggregation. Nephrotic syndrome, interstitial nephritis, hyperkalemia, sodium retention.
Half-Life (Normalesrd) Hours
1.0-1.5/Unchanged
Plasma Protein Binding %
>99
Volume Of Distribution L/Kg
0.1-0.14
Dose For Normal Renal Function
400 mg tid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Selley ML, Glass J, Triggs EJ, Thomas J. Pharmacokinetic studies of tolmetin in man. Clin Pharmacol Ther. 1975; 17: 599-605. [PMID: 1126116]
Toxicity Notes
Bronchodilators