Half-Life (Normalesrd) Hours
5-8/Unchanged
Plasma Protein Binding %
85-95
Volume Of Distribution L/Kg
0.15
Dose For Normal Renal Function
500 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Avoid
References
Cunningham RF, Israili ZH, Dayton PG. Clinical pharmacokinetics of probenecid. Clin Pharmacokinet. 1981; 6: 135-51. [PMID: 7011657] / Dayton PG, Perel JM. The metabolism of probenecid in man. Ann N Y Acad Sci. 1971; 179: 399-402. [PMID: 5285384]
Toxicity Notes
Ineffective at decreased GFR.