Half-Life (Normalesrd) Hours
1.5-3/Increased
Plasma Protein Binding %
80
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
250-1000 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 3 dose, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Netter P, Bannwarth B, Pé ré P, Nicolas A. Clinical pharmacokinetics of D-penicillamine. Clin Pharmacokinet. 1987; 13: 317-33. [PMID: 3319347]
Toxicity Notes
Nephrotic syndrome.