Colchicine

Excreted Unchanged %
5-17
Half-Life (Normalesrd) Hours
4/19-50
Plasma Protein Binding %
31
Volume Of Distribution L/Kg
4
Dose For Normal Renal Function
Acute: 2 mg, then 0.5 mg q6h Chronic: 0.5-1 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Terkeltaub RA. Clinical practice. Gout. N Engl J Med. 2003; 349: 1647-55. [PMID: 14573737] / Wallace SL, Omokoku B, Ertel NH. Colchicine plasma levels. Implications as to pharmacology and mechanism of action. Am J Med. 1970; 48: 443-8. [PMID: 5444299] / Wallace SL, Singer JZ, Duncan GJ, Wigley FM, Kuncl RW. Renal function predicts colchicine toxicity: guidelines for the prophylactic use of colchicine in gout. J Rheumatol. 1991; 18: 264-9. [PMID: 2023222]
Toxicity Notes
Avoid prolonged use if GFR <50 mL/min.