Half-Life (Normalesrd) Hours
1-2/Unchanged
Plasma Protein Binding %
80
Volume Of Distribution L/Kg
0.3-0.4
Dose For Normal Renal Function
100 mg tid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Cooper DS. Antithyroid drugs. N Engl J Med. 1984; 311: 1353-62. [PMID: 6387489]