General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
0.25/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
0.5
Dose For Normal Renal Function
500 mg/m2 q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: No data
References
Hall-Craggs M, Brenner DE, Vigorito RD, Sutherland JC. Acute renal failure and renal tubular squamous metaplasia following treatment with streptozotocin. Hum Pathol. 1982; 13: 597-601. [PMID: 6281169]
Toxicity Notes
Nephrotoxic. Proteinuria. Low serum phosphate. Renal tubular acidosis.