General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Half-Life (Normalesrd) Hours
2/No data
Plasma Protein Binding %
<10
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
25-30 µg/kg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: No data
References
Kennedy BJ. Metabolic and toxic effects of mithramycin during tumor therapy. Am J Med. 1970; 49: 494-503. [PMID: 4320120]
Toxicity Notes
Cumulative nephrotoxicity. Acute renal failure. Decrease serum Ca++, K+, phosphate.