Nitrosoureas

General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Excreted Unchanged %
>50
Half-Life (Normalesrd) Hours
Short/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
Varies
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25-50% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: No data
References
Ellis ME, Weiss RB, Kuperminc M. Nephrotoxicity of lomustine. A case report and literature review. Cancer Chemother Pharmacol. 1985; 15: 174-5. [PMID: 4017166] / Oliverio VT. Toxicology and pharmacology of the nitrosoureas. Cancer Chemother Rep 3. 1973; 4: 13-20. [PMID: 4201308]
Toxicity Notes
Nitrosoureas include carmustine (BCNU), lomustine (CCNU), and methyl-CCNU. Metabolites have variable T1/2. Irreversible toxicity at dose >1500 mg/m2.