Ifosfamide

General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Excreted Unchanged %
15
Half-Life (Normalesrd) Hours
4-10/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
0.4-0.64
Dose For Normal Renal Function
1.2 g/m2
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
75% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Fiedler R, Baumann F, Deschler B, Osten B. Haemoperfusion combined with haemodialysis in ifosfamide intoxication [Letter]. Nephrol Dial Transplant. 2001; 16: 1088-9. [PMID: 11328936] / Furlanut M, Franceschi L. Pharmacology of ifosfamide. Oncology. 2003; 65 Suppl 2: 2-6. [PMID: 14586139] / Wagner T. Ifosfamide clinical pharmacokinetics. Clin Pharmacokinet. 1994; 26: 439-56. [PMID: 8070218]
Toxicity Notes
Associated with Fanconi syndrome and renal dysfunction. Bladder toxicity may be reduced if given with mesna.