General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Half-Life (Normalesrd) Hours
No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
0.5
Dose For Normal Renal Function
20-30 mg/kg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
20% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Drugs of choice for cancer chemotherapy. Med Lett Drugs Ther. 1997; 39: 21-8. [PMID: 9081147] / Muggia FM, Von Hoff DD. In: Speight TM, Holford N, eds. Avery’ s Drug Treatment, 4th ed. Auckland: ADIS International; 1997: 1255.