General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
18-27/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
30-45 mg/m2
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Drugs of choice for cancer chemotherapy. Med Lett Drigs Ther. 1996; 39: 21-8. / Muggia FM, Von Hoff DD. In: Speight TM, Holford N, eds. Avery’ s Drug Treatment, 4th ed. Auckland: ADIS International; 1997: 1256.
Toxicity Notes
Cardiotoxicity and congestive heart failure.