General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Half-Life (Normalesrd) Hours
0.5-3/Unchanged
Plasma Protein Binding %
13
Volume Of Distribution L/Kg
2.6
Dose For Normal Renal Function
100-200 mg/m2
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Wan SH, Huffman DH, Azarnoff DL, Hoogstraten B, Larsen WE. Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine in humans. Cancer Res. 1974; 34: 392-7. [PMID: 4521089]