General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Excreted Unchanged %
10-15
Half-Life (Normalesrd) Hours
4.0-7.5/10
Plasma Protein Binding %
14-20
Volume Of Distribution L/Kg
0.5-1
Dose For Normal Renal Function
1-5 mg/kg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
75% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: dose, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
Toxicity Notes
Hemorrhagic cystitis. Bladder fibrosis and bladder cancer. Increased antidiuretic hormone secretion.