General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Excreted Unchanged %
27-45
Half-Life (Normalesrd) Hours
0.3-0.5/No data
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
0.5
Dose For Normal Renal Function
20-50 mg/m2 q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Yes, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Benisovich VI, Silverman L, Slifkin R, Stone N, Cohen E. Cisplatin-based chemotherapy in renal transplant recipients. A case report and a review of the literature. Cancer. 1996; 77: 160-3. [PMID: 8630924] / Blachley JD, Hill JB. Renal and electrolyte disturbances associated with cisplatin. Ann Intern Med. 1981; 95: 628-32. [PMID: 7027859] / Gormley PE, Bull JM, LeRoy AF, Cysyk R. Kinetics of cis-dichlorodiammineplatinum. Clin Pharmacol Ther. 1979; 25: 351-7. [PMID: 761445] / Hirai K, Ishiko O, Sumi T, Kanaoka Y, Ogita S. Kinetics of plasma platinum in a hemodialysis patient receiving repeated doses of cisplatin. Oncol Rep. 2000; 7: 1243-5.[PMID: 11032923]
Toxicity Notes
Nephrotoxic. Toxicity reduced by pretreatment hydration and Cl diuresis. Renal Mg++ wasting.