General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Excreted Unchanged %
0.5-3
Half-Life (Normalesrd) Hours
2.5-3.4/No data
Plasma Protein Binding %
3-15
Volume Of Distribution L/Kg
1.0
Dose For Normal Renal Function
4-8 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Ehrsson H, Hassan M, Ehrnebo M, Beran M. Busulfan kinetics. Clin Pharmacol Ther. 1983; 34: 86-9. [PMID: 6574831] / Millard RJ. Busulphan haemorrhagic cystitis. Br J Urol. 1978; 50: 210. [PMID: 288495]
Toxicity Notes
Hemorrhagic cystitis.