General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Half-Life (Normalesrd) Hours
9/20
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
0.3
Dose For Normal Renal Function
10-20 U/m2
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Bennett JM, Reich SD. Bleomycin. Ann Intern Med. 1979; 90: 945-8. [PMID: 87142] / Dalgleish AG, Woods RL, Levi JA. Bleomycin pulmonary toxicity: its relationship to renal dysfunction. Med Pediatr Oncol. / Skeel RT. Handbook of Cancer Chemotherapy, 3rd ed. Boston: Little, Brown; 1991.
Toxicity Notes
Drug accumulation predisposes to pulmonary fibrosis. Hypertension and dysuria.