General Toxicity Notes
Myelosuppressive and may aggravate uremic predisposition to hemorrhage and infection.
Half-Life (Normalesrd) Hours
0.16-1/Increased
Plasma Protein Binding %
20
Volume Of Distribution L/Kg
0.55-0.8
Dose For Normal Renal Function
1.5-2.5 mg/kg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Supplement 0.25 mg/kg, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Bach JF, Dardenne M. The metabolism of azathioprine in renal failure. Transplantation. 1971; 12: 253-9. [PMID: 4939818]
Toxicity Notes
6-Mercaptopurine is active metabolite. Subpopulation with genetic enzyme defects in metabolism (1% of population) may have severe toxicity.