Half-Life (Normalesrd) Hours
1.3-1.6/3.5-11
Plasma Protein Binding %
28-35
Volume Of Distribution L/Kg
0.8-1.3
Dose For Normal Renal Function
150-300 mg qhs
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
75-100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
150 mg q24-48h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
150 mg q48-72h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Aronoff GR, Bergstrom RF, Bopp RJ, Sloan RS, Callaghan JT. Nizatidine disposition in subjects with normal and impaired renal function. Clin Pharmacol Ther. 1988; 43: 688-95. [PMID: 2897890] / Price AH, Brogden RN. Nizatidine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in peptic ulcer disease. Drugs. 1988; 36: 521-39. [PMID: 2905640]
Toxicity Notes
For active duodenal ulcer, GERD, and benign gastric ulcer, use doses at higher level of recommended ranges. For maintenance therapy, use doses at lower level of recommended ranges.