Excreted Unchanged %
50-70
Half-Life (Normalesrd) Hours
1.5-2.0/5
Plasma Protein Binding %
13-25
Volume Of Distribution L/Kg
0.8-1.3
Dose For Normal Renal Function
400 mg bid
Second Dose
Second Dose: or 400-800 mg qhs
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
300 mg q8-12h [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50
References
Larsson R, Norlander B, Bodemar G, Walan A. Steady-state kinetics and dosage requirements of cimetidine in renal failure. Clin Pharmacokinet. 1981; 6: 316-25. [PMID: 7249490] / Ma KW, Brown DC, Masler DS, Silvis SE. Effects of renal failure on blood levels of cimetidine. Gastroenterology. 1978; 74: 473-7. [PMID: 620915] / Somogyi A, Gugler R. Clinical pharmacokinetics of cimetidine. Clin Pharmacokinet. 1983; 8: 463-95. [PMID: 6418428]
Toxicity Notes
Increases serum creatinine and decreases creatinine clearance by inhibition of creatinine secretion. Mental confusion with renal or hepatic disease. Acute renal failure.