General Toxicity Notes
May cause excessive sedation in ESRD.
Half-Life (Normalesrd) Hours
5/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
2.5 mg q4-6h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No data
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No data
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No data
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Cohen AF, Hamilton MJ, Liao SH, Findlay JW, Peck AW. Pharmacodynamic and pharmacokinetics of BW 825C: a new antihistamine. Eur J Clin Pharmacol. 1985; 28: 197-204. [PMID: 2859204] / Miles MV, Balasubramanian R, Pittman AW, Grossman SH, Pappa KA, Smith MF, et al. Pharmacokinetics of oral and transdermal triprolidine. J Clin Pharmacol. 1990; 30: 572-5. [PMID: 2355108] / Simons KJ, Singh M, Gillespie CA, Simons FE. An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol. 1986; 77: 326-30. [PMID: 3944383]
Toxicity Notes
Not much known about effects on renal function.