General Toxicity Notes
May cause excessive sedation in ESRD.
Half-Life (Normalesrd) Hours
2.9-4.4/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
10
Dose For Normal Renal Function
25-50 mg tid-qid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No data
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No data
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No data
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Yeh SY. Metabolic profile of tripelennamine in humans. J Pharm Sci. 1991; 80: 815-9. [PMID: 1800700] / Yeh SY, Todd GD, Johnson RE, Gorodetzky CW, Lange WR. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986; 39: 669-76. [PMID: 3709032]
Toxicity Notes
Not very effective as an antihistamine.