General Toxicity Notes
May cause excessive sedation in ESRD.
Half-Life (Normalesrd) Hours
16/No data
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
100 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Ellison T. Metabolic studies of 3 H-orphenadrine citrate in the rat, dog and rhesus monkey. Arch Int Pharmacodyn Ther. 1972; 195: 213-30. [PMID: 4622666] / Ellison T, Snyder A, Bolger J, Okun R. Metabolism of orphenadrine citrate in man. J Pharmacol Exp Ther. 1971; 176: 284-95. [PMID: 5568779]
Toxicity Notes
Highly lipophilic. Suspect large volume of distribution.