General Toxicity Notes
May cause excessive sedation in ESRD.
Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
14-20/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
19.5
Dose For Normal Renal Function
50-100 mg qid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50%, [D]
References
Simons KJ, Watson WT, Chen XY, Simons FE. Pharmacokinetic and pharmacodynamic studies of the H1-receptor antagonist hydroxyzine in the elderly. Clin Pharmacol Ther. 1989; 45: 9-14. [PMID: 2562944]
Toxicity Notes
Accumulates in ESRD. Cetirizine is the active metabolite of hydoxyzine.