General Toxicity Notes
May cause excessive sedation in ESRD.
Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
17-18 days/No data
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
43-78
Dose For Normal Renal Function
10-20 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: None, [D]
References
Holmes B, Brogden RN, Heel RC, Speight TM, Avery GS. Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drugs. 1984; 27: 6-44. [PMID: 6141044]