General Toxicity Notes
May cause excessive sedation in ESRD.
Half-Life (Normalesrd) Hours
14/19-25
Plasma Protein Binding %
60-70
Volume Of Distribution L/Kg
8-10
Dose For Normal Renal Function
60 mg bid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 60 mg q24h, [D]
References
Fexofenadine. Med Lett Drugs Ther. 1996; 38: 95-6. / Hamman MA, Bruce MA, Haehner-Daniels BD, Hall SD. The effect of rifampin administration on the disposition of fexofenadine. Clin Pharmacol Ther. 2001; 69: 114-21. [PMID: 11240975]