General Toxicity Notes
May cause excessive sedation in ESRD.
Half-Life (Normalesrd) Hours
8-15
Plasma Protein Binding %
No Data
Volume Of Distribution L/Kg
2.6-3.2
Dose For Normal Renal Function
25 mg hs
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Friedman H, Greenblatt DJ, Scavone JM, Burstein ES, Ochs HR, Harmatz JS, et al. Clearance of the antihistamine doxylamine. Reduced in elderly men but not in elderly women. Clin Pharmacokinet. 1989; 16: 312-6. [PMID: 2743704] / Luna BG, Scavone JM, Greenblatt DJ. Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives. J Clin Pharmacol. 1989; 29: 257-60. [PMID: 2723113] / Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991.
Toxicity Notes
Anticholinergic effects.