Diphenhydramine

General Toxicity Notes
May cause excessive sedation in ESRD.
Excreted Unchanged %
2
Half-Life (Normalesrd) Hours
5.3-11.7/No data
Plasma Protein Binding %
80
Volume Of Distribution L/Kg
3.3-6.8
Dose For Normal Renal Function
25 mg tid-qid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Blyden GT, Greenblatt DJ, Scavone JM, Shader RI. Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration. J Clin Pharmacol. 1986; 26: 529-33. [PMID: 3760245] / Gilman AG, Goodman LS, Gilman AG, et al, eds. Goodman & Gilman&#146; s The Pharma-cological Basis of Therapeutics, 6th ed. New York: Macmillan; 1980. / Simons KJ, Watson WT, Martin TJ, Chen XY, Simons FE. Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children. J Clin Pharmacol. 1990; 30: 665-71. [PMID: 2391399]
Toxicity Notes
Anticholinergic effects may cause urinary retention.