Dimenhydrinate

General Toxicity Notes
May cause excessive sedation in ESRD.
Excreted Unchanged %
No data
Half-Life (Normalesrd) Hours
4-7/No data
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
50-100 mg q4-6h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q4-6h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q6-8h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q8h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Gilman AG, Goodman LS, Gilman AG, et al, eds. Goodman & Gilman&#146; s The Pharma-cological Basis of Therapeutics, 6th ed. New York: Macmillan; 1980. / Scavone JM, Luna BG, Harmatz JS, von Moltke L, Greenblatt DJ. Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration. Biopharm Drug Dispos. 1990; 11: 185-9. [PMID: 2328304] / Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991.
Toxicity Notes
Little information is available on the distribution and metabolic fate of dimenhydrinate. Like other antihistamines, the drug probably is widely distributed into body tissues, crosses the placenta, and is metabolized by the liver. Contains 55% diphenhydramine (q.v.) and 45% 8-chlorotheophylline.