General Toxicity Notes
May cause excessive sedation in ESRD.
Excreted Unchanged %
0.3-26
Half-Life (Normalesrd) Hours
14-24/No data
Plasma Protein Binding %
67-73
Volume Of Distribution L/Kg
2.9-3.5
Dose For Normal Renal Function
4.0 mg q4-6h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Rumore MM. Clinical pharmacokinetics of chlorpheniramine. Drug Intell Clin Pharm. 1984; 18: 701-7. [PMID: 6383755]
Toxicity Notes
Renal excretion increases with urine flow and lower pH.