General Toxicity Notes
May cause excessive sedation in ESRD.
Excreted Unchanged %
63-79
Half-Life (Normalesrd) Hours
7-10/20-30
Plasma Protein Binding %
93
Volume Of Distribution L/Kg
0.4-0.6
Dose For Normal Renal Function
5-10 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
5-10 mg qd [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
5 mg qd [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
5 mg qd [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Awni WM, Yeh J, Halstenson CE, Opsahl JA, Chung M, Matzke GR. Effect of haemodialysis on the pharmacokinetics of cetirizine. Eur J Clin Pharmacol. 1990; 38: 67-9. [PMID: 1970299] / Matzke GR, Yeh J, Awni WM, Halstenson CE, Chung M. Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency. Ann Allergy. 1987; 59: 25-30. [PMID: 2892446] / Noiri E, Ozawa H, Fujita T, Nakao A. Pharmacokinetics of cetirizine in chronic hemodialysis patients: multiple-dose study. Nephron. 2001; 89: 101-4. [PMID: 11528239]
Toxicity Notes
5 mg three times a week may be effective for ESRD patients on HD.