General Toxicity Notes
May cause excessive sedation in ESRD.
Half-Life (Normalesrd) Hours
16-34/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
8-14
Dose For Normal Renal Function
4.0 mg q4-6h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for normal GFR, no supplement required, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for normal GFR, no supplement required, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Simons FE, Frith EM, Simons KJ. The pharmacokinetics and antihistaminic effects of brompheniramine. J Allergy Clin Immunol. 1982; 70: 458-64. [PMID: 6128358]