General Toxicity Notes
May cause excessive sedation in ESRD.
Half-Life (Normalesrd) Hours
9-12/No data
Plasma Protein Binding %
36-43
Volume Of Distribution L/Kg
0.9
Dose For Normal Renal Function
1-2 mg bid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q12-24h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Seyffart G. Drug Dosage in Renal Insufficiency. Dordrecht, The Netherlands: Kluwer Academic; 1991.