Half-Life (Normalesrd) Hours
5-7/13-15
Plasma Protein Binding %
<5
Volume Of Distribution L/Kg
0.8
Dose For Normal Renal Function
1-2 g bid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q24h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q48h [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q48-72h [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Bachmann D, Ritz R, Wad N, Haefeli WE. Vigabatrin dosing during haemodialysis. Seizure. 1996; 5: 239-42. [PMID: 8902928] / Haegele KD, Huebert ND, Ebel M, Tell GP, Schechter PJ. Pharmacokinetics of vigabatrin: implications of creatinine clearance. Clin Pharmacol Ther. 1988; 44: 558-65. [PMID: 3180638] / Schechter PJ. Clinical pharmacology of vigabatrin. Br J Clin Pharmacol. 1989; 27 Suppl 1: 19S-22S. [PMID: 2667604]
Toxicity Notes
Encephalopathy with drug accumulation.