Half-Life (Normalesrd) Hours
6-8/25
Plasma Protein Binding %
<10
Volume Of Distribution L/Kg
0.5-0.7
Dose For Normal Renal Function
500-1500 mg q12h
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
500-1000 mg q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
250-750 mg q12h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
500-1000 mg q24h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 250-500 mg after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 250-750 mg q12h, [D]
References
Patsalos PN. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol Ther. 2000; 85: 77-85. [PMID: 10722121]