Half-Life (Normalesrd) Hours
25-30/57
Plasma Protein Binding %
55
Volume Of Distribution L/Kg
0.9-1.3
Dose For Normal Renal Function
50 mg q12-24h (initially) 100-500 mg q24h (maintenance)
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100 mg qod [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100 mg after dialysis, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Decrease dose by 50%, [B]
References
Cohen AF, Land GS, Breimer DD, Yuen WC, Winton C, Peck AW. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clin Pharmacol Ther. 1987; 42: 535-41. [PMID: 3677542] / Fillastre JP, Taburet AM, Fialaire A, Etienne I, Bidault R, Singlas E. Pharmacokinetics of lamotrigine in patients with renal impairment: influence of haemodialysis. Drugs Exp Clin Res. 1993; 19: 25-32. [PMID: 8223137] / Rambeck B, Wolf P. Lamotrigine clinical pharmacokinetics. Clin Pharmacokinet. 1993; 25: 433-43. [PMID: 8119045]