Gabapentin

Excreted Unchanged %
90
Half-Life (Normalesrd) Hours
5-7/132
Plasma Protein Binding %
<3
Volume Of Distribution L/Kg
0.7
Dose For Normal Renal Function
300-600 mg tid
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
400 mg tid [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
300 mg q12-24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
300 mg qod [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 300 mg load, then 200-300 mg post HD, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: 300 mg qod, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Bialer M. Comparative pharmacokinetics of the newer antiepileptic drugs. Clin Pharmacokinet. 1993; 24: 441-52. [PMID: 8513648] / Blum RA, Comstock TJ, Sica DA, Schultz RW, Keller E, Reetze P, et al. Pharmaco-kinetics of gabapentin in subjects with various degrees of renal function. Clin Pharmacol Ther. 1994; 56: 154-9. [PMID: 8062491] / Wong MO, Eldon MA, Keane WF, T&#252; rck D, Bockbrader HN, Underwood BA, et al. Disposition of gabapentin in anuric subjects on hemodialysis. J Clin Pharmacol. 1995; 35: 622-6. [PMID: 7665723]