Excreted Unchanged %
40-50
Half-Life (Normalesrd) Hours
20-23/34
Plasma Protein Binding %
22-25
Volume Of Distribution L/Kg
0.76
Dose For Normal Renal Function
400 mg tid first week
Second Dose
Second Dose: 800-1200 mg tid by weekly titration
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
75-100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-75% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Decrease dose by 50%, [D]
References
Glue P, Sulowicz W, Colucci R, Banfield C, Pai S, Lin C, et al. Single-dose pharmacokinetics of felbamate in patients with renal dysfunction. Br J Clin Pharmacol. 1997; 44: 91-3. [PMID: 9241102]
Toxicity Notes
Aplastic anemia, hepatic failure. Non-renal clearance decreases by 30-35% in uremia.