Excreted Unchanged %
17-40
Half-Life (Normalesrd) Hours
35-55/Unchanged
Plasma Protein Binding %
<5
Volume Of Distribution L/Kg
0.6-0.9
Dose For Normal Renal Function
500-1500 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
75% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for normal renal function after dialysis, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for normal renal function, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, not on market
References
Buchanan RA, Kinkel AW, Smith TC. The absorption and excretion of ethosuximide. Int J Clin Pharmacol. 1973; 7: 213-8. [PMID: 4731287] / Goulet JR, Kinkel AW, Smith TC. Metabolism of ethosuximide. Clin Pharmacol Ther. 1976; 20: 213-8. [PMID: 780040] / Marbury TC, Lee CS, Perchalski RJ, Wilder BJ. Hemodialysis clearance of ethosuximide in patients with chronic renal disease. Am J Hosp Pharm. 1981; 38: 1757-60. [PMID: 7304633]