Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
34-45/Unchanged
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
0.15
Dose For Normal Renal Function
10-15 mg load, then 2-10 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
Toxicity Notes
Follow INR. Decreased protein binding in uremia.