Half-Life (Normalesrd) Hours
1.5/No data
Plasma Protein Binding %
3
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
25 mg/kg tid-qid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
50% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
25% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
10% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Astedt B. Clinical pharmacology of tranexamic acid. Scand J Gastroenterol Suppl. 1987; 137: 22-5. [PMID: 3321402] / Pilbrant A, Schannong M, Vessman J. Pharmacokinetics and bioavailability of tranexamic acid. Eur J Clin Pharmacol. 1981; 20: 65-72. [PMID: 7308275]