Half-Life (Normalesrd) Hours
24-33/No data
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
250 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Kelly JG, O’ Malley K. Clinical pharmacokinetics of oral anticoagulants. Clin Phar-macokinet. 1979; 4: 1-15. [PMID: 369763] / Saltiel E, Ward A. Ticlopidine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states. Drugs. 1987; 34: 222-62. [PMID: 3304967] / VanPeer A, Belpaire F, Bogaert M. Warfarin elimination and responsiveness in patients with renal dysfunction [Letter]. J Clin Pharmacol. 1978; 18: 84. [PMID: 618922]