Excreted Unchanged %
25-50
Half-Life (Normalesrd) Hours
2.2-5.0/Unchanged
Plasma Protein Binding %
>95
Volume Of Distribution L/Kg
0.06
Dose For Normal Renal Function
200 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not Applicable
References
Margulies EH, White AM, Sherry S. Sulfinpyrazone: a review of its pharmacological properties and therapeutic use. Drugs. 1980; 20: 179-97. [PMID: 7000488] / Pedersen AK, Jakobsen P, Kampmann JP, Hansen JM. Clinical pharmacokinetics and potentially important drug interactions of sulphinpyrazone. Clin Pharmacokinet. 1982; 7: 42-56. [PMID: 7042172]
Toxicity Notes
Acute renal failure. Uricosuric effect at low GFR. Ineffective in renal insufficiency.