Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
0.6-1.5/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
0.02-0.08
Dose For Normal Renal Function
250,000 U load, then 100,000 U/h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Grierson DS, Bjornsson TD. Pharmacokinetics of streptokinase in patients based on amidolytic activator complex activity. Clin Pharmacol Ther. 1987; 41: 304-13. [PMID: 3816018]
Toxicity Notes
Rarely used because of newer agents.