Half-Life (Normalesrd) Hours
6-7/27-33
Plasma Protein Binding %
>99
Volume Of Distribution L/Kg
0.18-0.21
Dose For Normal Renal Function
100-200 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Savazzi GM, Castiglioni A, Cavatorta A. Effect of renal insufficiency on the pharmacokinetics of indobufen. Curr Therap Res. 1984; 36: 119-25. [PMID unavailable] / Wiseman LR, Fitton A, Buckley MM. Indobufen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in cerebral, peripheral and coronary vascular disease. Drugs. 1992; 44: 445-64. [PMID: 1382938]