Excreted Unchanged %
No data
Half-Life (Normalesrd) Hours
2.2-6.0/4-10
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
0.06-0.13
Dose For Normal Renal Function
30-40 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50% and monitor Xa, [D]
References
Weitz JI. Low-molecular-weight heparins. N Engl J Med. 1997; 337: 688-98. [PMID: 9278467]
Toxicity Notes
Bleeding may be enhanced in patients with uremic platelet defects.